5 edition of The GTPase superfamily found in the catalog.
|Statement||[editors, Joan Marsh (organizer) and Jamie Goode].|
|Series||Ciba Foundation symposium ;, 176|
|Contributions||Marsh, Joan., Goode, Jamie.|
|LC Classifications||QP552.G16 G87 1993|
|The Physical Object|
|Pagination||x, 289 p. :|
|Number of Pages||289|
|LC Control Number||93010294|
GTPases (singular GTPase) are also called GAP and they are a large family of hydrolase enzymes that can bind and hydrolyze GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases.. They help GTP binding proteins hydrolyse GTP and be converted to their ground state. RAS-like GTPase Transport Protein: This protein from M. tuberculosis is a member of the Ras super family of proteins. Ras is involved in signal transduction and activating mutations in human Ras are associated with many types of cancer. While originally annotated as an arginine/ornithine transport system ATPase, we show that the protein is most likely a GTPase based on the .
The GTPase Activating Proteins accelerate intrinsic GTPase by a factor of 10^5 to 10^6. Ras, Rap, Rho, Rab, Ran have completely unrelated GAPs. High affinity binding to the GTP-bound form, low affinity interaction with the GDP-bound form. The methods cover the spectrum of core techniques required for the five major GTPase subfamilies (Ras, Rho, Rab, Arf, and Ran) and permit a diversity of applications ranging from structural studies on a GTPase to real time in vivo analysis. This book illuminates the techniques used to study this family of proteins.
Rho family GTPases belong to the Ras GTPase superfamily and transduce intracellular signals known to regulate a variety of cellular processes, including cell polarity, morphogenesis, migration, apoptosis, vesicle trafficking, viral transport and cellular transformation. The three best-characterized Rho family members are Cdc42, RhoA and Rac1. Microbiology gateway. Information, current research and relevant technology on all aspects of microbiology and molecular biology. Reviews and documents on topical aspects of microbiology, molecular biology and PCR including metagenomics, qPCR, real-time PCR, nanotechnology, genomic analysis, DNA sequencing and computational biology.
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In GTPase Protocols: The Ras Superfamily, Edward J. Manser and Thomas Leung have collected the key techniques currently in use to probe the function of these ubiquitous proteins both in vitro and in vivo.
Presented in a format that ensures ready reproducibility by accomplished experimentalists who have refined the various methods in their Format: Hardcover. About this book Using a multidisciplinary approach, it features contributions and discussions of the latest research from leading scientists working on all aspects of GTPase activity.
Covers all known members of the important superfamily of enzymes--the GTPases. ISBN: OCLC Number: Notes: "Symposium on the GTPase superfamily, held at the Ciba Foundation, London, November "--Page [v]. The Ras superfamily of small GTPases includes more than human members that can be subdivided into several structurally or functionally related families conserved in evolution: Ras, Rho, Rab, Arf, and Ran (Figure A) The GTPase superfamily book superfamily proteins are highly conserved within the core G domain and share a common topology that governs their activity and interaction.
Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction).Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell InterPro: IPR COVID Resources.
Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource The GTPase superfamily book are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle.
Small GTPase binding proteins (GTPases) are an ancient group of proteins that play key roles in almost every aspect of cell biology, from cell proliferation to nuclear transport.
In GTPase Protocols: The Ras Superfamily, Edward J. Manser and Thomas Leung have collected the key techniques currently in use to probe the function of these. The GTPase domain is the most highly conserved region.
Compared with the Ras superfamily, dynamin has an unusually high GTPase activity and low affinity for GTP. Thus, it has a low basal GTPase activity which is controlled by self-assembly or lipid binding. Mutations in the GTPase domain such as K44A, K44E, and S45N are defective in GTP binding.
Small GTPases of the Ras superfamily are key regulators of diverse cellular and developmental events, including differentiation, cell division, vesicle transport, nuclear assembly, and control of the cytoskeleton. The C. elegans genome encodes 56 members of the major Ras GTPase subfamilies, including the Ras/Ral/Rap family, the Rho family, the Rab family, Ran, Author: Erik A.
Lundquist. Identification and Classification of Small GTPase Genes in Arabidopsis. To identify small GTPase genes in the Arabidopsis genome, we first compiled sequences previously documented in S. cerevisiaeand humans as members of the small GTP-binding protein superfamily of regulatory genes were classified into the five accepted families.
outside the small GTPase/Ras superfamily. Small GTPases 2. Overview The Ras (Rat sarcoma) superfamily of small GTPases is an ancient group of molecular switches whose functions have radiated phylogenetically to encompass broad areas of cell biology.
The founding members of theFile Size: 2MB. Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity.
The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. Title:Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design VOLUME: 17 ISSUE: 1 Author(s):Wenye Zhao, Mostafa Jamshidiha, Thomas Lanyon-Hogg, Chiara Recchi, Ernesto Cota and Edward W.
Tate Affiliation:Department of Chemistry, Imperial College London, London SW7 2AZ, United Kingdom. Keywords:Cancer, Fragment-based drug Cited by: 7. GTPase Protocols. The Ras Superfamily | Ed Manser, Thomas Leung | download | B–OK. Download books for free.
Find books. The small GTPase superfamily comprises monomeric GTP-binding proteins with molecular masses usually in the range of kDa. The small GTPase superfamily has been found in all eukaryotic organisms, ranging from Giardia to human Small GTPase Superfamily The small GTPase superfamily comprises monomeric GTP-binding proteins with molecular masses.
The Ras superfamily of small GTPases is composed of more than members, which share a conserved structure and biochemical properties, acting as binary molecular switches turned on by binding GTP and off by hydrolyzing GTP to by: The major groups in the RAS superfamily are represented.
Purpose: The aim is to provide a set of standardized protocols for working with this group of proteins. This is a suitable objective and largely achieved.
Audience: This book is intended for use by investigators wishing to study one of the RAS family GTPases. The protocols are usable by Price: $ The ancient translational GTPase (trGTPase) superfamily includes a number of essential proteins, some of which originated before the last common ancestor of all life (LUCA).
These GTP hydrolyzing enzymes function in a variety of cellular processes including core roles in the four stages of protein synthesis: initiation, elongation, termination.
The GTPase cycle. Ras-superfamily GTPases bound to GTP are active signaling molecules. The intrinsic GTPase activity of the molecule hydrolyzes GTP to GDP, and GDP-bound forms are inactive. GTPase activating proteins (GAPs) enhance GTPase activity and favor the inactive, GDP-bound state. Members of the Rab and Arf branches of the Ras GTPase superfamily are present in every step of intracellular membrane traffic.
They regulate these steps by networking with one another through a variety of mechanisms that coordinate independent events of one stage together with other stages of the entire transport pathway. GTPase Protocols: The Ras Superfamily Ed Manser, Thomas Leung Edward J.
Manser and Thomas Leung have collected the key techniques currently in use to probe the function of these ubiquitous proteins both in vitro and in vivo.The Gtpase Superfamily -No. by Ciba Foundation Symposium, Jamie Goode (Editor), Joan Marsh (Editor) About this title: Using a multidisciplinary approach, it features contributions and discussions of the latest research from leading scientists working .The GTPase superfamily (Ciba foundation symposium ) edited by Joan Marsh and Jamie Goode, John Wiley,£ ( pages) ISBN 0 5Cited by: 1.